Evaluation of The Relationship Between the Frequency of Attacksand Vitamin Levels in Patients Admitted to The Emergency Department With Migraine Headache
Introduction: Migraine is a common multifactorial, neurovascular primary headache disorder that develops due to the increased excitability of the central nervous system (CNS) and causes limitations in the quality of life of individuals. In this study, it was aimed to evaluate the relationship between the frequency of attacks and vitamin levels of patients who had migraine attacks and presented to the emergency department with a migraine attack.
Method: The study is a retrospective cross-sectional study. 54 patients who were diagnosed with migraine headache according to the International Headache classification between January 1, 2019, and January 1, 2020, in the Emergency Medicine clinic of Yozgat Bozok University (Group 1). There was no history of systemic diseases such as diabetes mellitus, hypertension, heart disease, or goiter. The control group consisted of individuals who were examined for a general medical examination during the same period, whose migraine history was not in their anamnesis and history, and who did not receive vitamin supplements (Group 2). Mann-Whitney U test was used in statistical evaluations according to the status of the statistically nonparametric variables and the correlated variables were categorical (nominal or ordinal) and numerical independent group. Spearman rank correlation method was used in nonparametric data for correlations between data. The results were evaluated for a significance level of p <0.05.
Results: A total of 51.4% (n = 54) migraine patients (Group 1) and 48.6% (n = 51) healthy control group (Group 2) were included in the study. Of group 1 patients, 85.7% (n = 46) were female and 14.3% (n = 8) were male. Vitamin B12, Folate and Vitamin D levels were significantly lower in Group 2 (<0.05). While there was a moderate negative correlation with vitamin D level, there was a weak negative correlation with vitamin B12 and Folate parameters (<0.05). Vitamin D level was found to be significantly lower in migraine patients with aura in the migraine patient group (<0.05).
Conclusion: Especially vitamin D, vitamin B12, and folate levels have an important place among the causes of migraine headaches. Besides, we think that low Vitamin D level is important in migraine-type with aura. Therefore, prospective studies are needed, especially on vitamin D and migraine subgroups.
Key words: vitamin D, vitamin B12, Migraine, emergency department
Eurasian J Critical Care 2021; 3 (1):25-28 Original Article